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Mar 5, 2025 · Design, synthesis and characterization of novel thiazolidinone derivatives: Insights from a network pharmacology approach for breast cancer therapy
For Cleavage. 4-Thiazolidinone was obtained in >90% yield (95% purity) after photolytic cleavage in pH 7.4 phosphate-buffered saline (PBS) containing 5% DMSO (simulating a cleavage …
Feb 15, 2022 · 4-Thiazolidinone system is a core structure in various synthetic targets displaying broad spectrum of biological activities especially as anticancer agents [9], [10], [11], [12], [13], …
When it comes to developing therapeutic drugs, thiazolidinone derivatives are beneficial due to their strong antibacterial, anticancer, anti-inflammatory, and antioxidant properties 11,12. Their …
ABSTRACT: A small library of novel thiazolidinone-based sulfonamide derivatives was designed, synthesized and evaluated for their ability to target human carbonic anhydrase (hCA) isoforms …
May 1, 2025 · To elucidate the structure-activity relationships (SARs) of thiazolidinone derivatives as chitinase inhibitors and guide further structural optimization, 3D QSAR models of cinnamyl …
Dec 1, 2017 · In the modern scenario, thiazolidinone scaffold has emerged as a very potent scaffold as per its clinical significance concerned. It has attracted the keen interest of the …
Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone …
Jul 19, 2023 · Figure 10. Synthesis of thiazolidinone by Rajalakshmi et al. Novel Thiazinyl-thiazolidinone compounds have been created by Rajalakshmi et al. [24], as potential in vitro …
This broad diversity in biological activities gives more attention to synthesizing more new thiazolidinone derivatives and to studying mechanisms of action. Figure.1. Different …
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